AB-452663-1 THE IMPACT OF LOW POSTERIOR LEFT ATRIAL WALL VOLTAGE ON THE OUTCOMES OF CATHETER ABLATION FOR PERSISTENT ATRIAL FIBRILLATION: A CAPLA RANDOMIZED CLINICAL TRIAL SUBSTUDY
نویسندگان
چکیده
Pulmonary vein isolation(PVI) is less effective in patients with persistent atrial fibrillation(PsAF). Adjunctive ablation targeting low voltage areas(LVA) had demonstrated improved arrhythmia outcomes. To compare the outcomes of adding posterior wall isolation(PWI) to PVI, versus PVI alone, PsAF LVA. The CAPLA study was a multi-centre, randomized trial involving 1:1 either alone or PWI. Voltage mapping performed during pacing pre-ablation reviewed offline, LVA defined as bipolar <0.5mV. primary endpoint freedom from any documented >30 seconds off anti-arrhythmic medication (AAD) at 12 months, after single procedure 210 (average 64.6+/-9.2years,73.3% males)underwent multipolar LA mapping. Posterior present 32.9%(median surface area 0.6cm2), and associated larger left diameter(4.8cm vs 4.4cm, p<0.01). addition PWI did not significantly improve recurrence over alone(PVI 44.8% 41.9%, HR0.95, 95%CI0.51-1.79; p=0.95). Compared no LVA, were more likely have other regions(91.7% 57.1%, p<0.01), increased risk months (LVA 78.2% 44.2%; HR1.51, 95%CI 1.01-2.27, p=0.04). In undergoing catheter ablation, significant increase recurrence. However, those reduce alone.
منابع مشابه
Optimal rhythm-control strategy for recurrent atrial tachycardia after catheter ablation of persistent atrial fibrillation: a randomized clinical trial.
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ژورنال
عنوان ژورنال: Heart Rhythm
سال: 2023
ISSN: ['1556-3871', '1547-5271']
DOI: https://doi.org/10.1016/j.hrthm.2023.03.305